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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Icaritin, TNF-related apoptosis inducing ligand
Phytochemical Name Icaritin (PubChem CID: 5318980 )
Anticancer drug Name TNF-related apoptosis inducing ligand (PubChem CID: / )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 422
Ref_1
Pair Name Icaritin, TNF-related apoptosis inducing ligand
Disease Info [ICD-11: 2A00] Glioblastoma multiforme Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Cleavage CASP3 hsa836
Down-regulation Expression CFLAR hsa8837
Up-regulation Cleavage PARP1 hsa142
Down-regulation Expression RELA hsa5970
In Vitro Model U-373MG ATCC Astrocytoma Homo sapiens (Human) CVCL_2219
U-87MG ATCC Glioblastoma Homo sapiens (Human) CVCL_0022
Result These data suggest that icaritin sensitizes TRAIL-induced tumor cell apoptosis via suppression of NF-κB-dependent c-FLIP expression, providing in vitro evidence supporting the notion that icaritin is a potential sensitizer of TRAIL in anticancer therapy against human GBM.
03. Reference
No. Title Href
1 Icaritin Sensitizes Human Glioblastoma Cells to TRAIL-Induced Apoptosis. Cell Biochem Biophys. 2015 Jun;72(2):533-42. doi: 10.1007/s12013-014-0499-y. Click
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